Research Scientist (M/F)
Qubit Pharmaceuticals is looking for two Research Scientists, to help build the RNA platform, as part of the project: "Targeting RNA and RNA-protein interactions using small molecules".
The work will focus on RNA and RNA/RBP complex structure and dynamics as well as their interactions with small molecules. Polarizable molecular dynamics simulations will be used to understand the system and free energy simulations will be used to design the interactions with small molecules and propose more effective ligands. This will be done using the massively parallel software Tinker-HP and the multipolar polarizable force field AMOEBA. Advanced molecular dynamics simulation methods will also be developed and applied, to ensure adequate sampling of conformations and converged free energies.
The perfect fit for this job
At Qubit Pharmaceuticals, we are looking for talented individuals with a passion for the latest quantum technologies that can bring new ideas to problem solving and desire to apply them to design better drugs, faster. Candidate who is a great team collaborator, and open to ask questions when it is needed.
Your role
Quantum chemistry calculations
Molecular dynamics simulations
Structural dynamics analysis of the systems as well as interaction pattern analysis
Free energy simulations
Small molecule parameterization
Methods development
Reporting monthly activities and contributing to scientific article writing
Interacting with other teams
Your Qualifications
PhD in physical chemistry, theoretical chemistry, biophysics, or a related field.
A minimum of 7 years of experience in the field (including PhD)
Knowledge of RNA structural dynamics / RBP and RNA mechanism and interactions as well as interactions with small molecules is strongly preferred
Knowledge of quantum chemistry is strongly preferred
Knowledge of Molecular dynamics simulation is essential
Knowledge in Free energy simulations is essential
Knowledge in statistical mechanics is strongly preferred
Knowledge in advanced sampling techniques is essential
Very good knowledge of written and spoken English
Good communication skills
The proposal benefits & perks
Duration: Full time – Permanent
Salary according to profile
Health insurance and provident fund 100% covered
Lunch vouchers worth €9 covered at 50%.
Location: Paris 14th
Possibility to work from home for 2 days/week
- Département
- Drug Discovery
- Role
- Research Scientist (M/F)
- Locations
- Paris Cochin
- Remote status
- Temporarily Remote
Perks and benefits
-
Health insurance
-
Retirement plan
-
Hybrid work
-
Meal vouchers
-
Regular team socials
Workplace and culture
We're a diverse mix of expertise, experience and perspectives, united around the passion to make a positive impact in drug design and discovery using the best computational technology.
We’re proud of our inclusive culture where individuals are encouraged to collaborate, lead and grow.
Our Values:
We live and work by our values:
- We care genuinely
- We encourage diversity
- We value scientific excellence
- We foster resilience
- We succeed together
Paris Cochin
About Qubit Pharmaceuticals
Lifesaving treatments, one atom at a time.
Anything is Druggable - with Quantum Accuracy.
We are a physics driven drug discovery company. Using advanced simulation software and AI-enhanced medicinal chemistry, we develop novel drug candidates and innovative mode of action against challenging targets.
We design our drug candidates atom by atom to optimize their efficiency and their specificity with a favorable safety profile at unprecedented speed.
Research Scientist (M/F)
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